Shirlene \sh(i)-rle-ne, shir-lene\ as a girl's name is a variant of Shirley (Old English), and the meaning of Shirlene is "bright meadow".

The baby name Shirlene sounds like Sharlene, Sherlene and Shirline. Other similar baby names are Shirlee, Sharline, Charlene, Sharlyne, Sharlena, Shslene, Shalene, Sharleyne, Sharlee, Sharlane, Sharene, Shaylene, Sherelene, Shurlee, Shirlyn, Shirleen, Shirlea and Sherlee.