Antonio \a-nto-nio, an-tonio\ as a boy's name is pronounced an-TOH-nee-oh. It is of Spanish and Italian origin. Variant of Anthony. This form is even more popular than Antoine, likely due to the number of Spanish-speaking immigrants to America. Saint Anthony of Padua is a very important saint in the Catholic church, venerated on June 13. Football player Antonio Freeman; actor Antonio Banderas.