Cherokee \ch(e)-ro-kee\ as a boy's name is pronounced CHARE-oh-kee. It is of Native American Indian origin, and the meaning of Cherokee is "people of a different speech". The name of one of the largest Native American tribes, used as a given name. The Cherokee originally lived in the southeastern America. They were farmers, and one of the first tribes to produce a written language.

A baby name that sounds like Cherokee is Shiriki. Another similar baby name is Cheroot.