Dewayne \de-wayne, dewa(y)-ne\ as a boy's name is a variant of De- (American), Duane (Irish, Gaelic) and Dwayne (Irish, Gaelic), and the meaning of Dewayne is "dark, swarthy".

The baby name Dewayne sounds like Dawayne and Duwayne. Other similar baby names are Lewayne, Dayne, Devane, Deane, Delane, Delaine, Dwaine, Duwaine, Duayne, Dewain, Dwane, Gwayne, Gawayne and Swayne.