Efren \e-fren, ef-ren\ as a boy's name is a variant of Efrain (Spanish, Hebrew), and the meaning of Efren is "fruitful".

The baby name Efren sounds like Efran, Efron and Efryn. Other similar baby names are Efrem, Erin, Efrim, Efrat, Efroni, Eran, Eron and Even.