Isaac \i-saac\ as a boy's name is pronounced EYE-zik. It is of Hebrew origin, and the meaning of Isaac is "laughter". Biblical: the only son of Abraham by his wife Sarah. Violinist Itzhak (ITS-hahk) Perlman; scientish Isaac Newton; angler Izaak Walton; authors Isaac Bashevis Singer, Isaac Asimov; football player Isaac Bruce; singer Isaac Hanson.
A baby name that sounds like Isaac is Osage.