James \j(a)-mes\ as a boy's name (also used as girl's name James), is pronounced jayms. It is of Hebrew origin, and the meaning of James is "he who supplants". Variant of Jacob. Biblical: one of the 12 apostles of Jesus, who possibly was also a cousin of Jesus. The King James Bible is named in reference to James I of England (16th-17th century). Spanish pronunciation of Jaime: (HYE-may), Scottish: (JAY-mee). See also Kimo and Santiago. Writer James Joyce; actors James Mason, James Caviezel, James Gandolfini, Jimmy Stewart; entertainer Jimmy Durante; American Presidents Hames Buchanan, James Garfield, James Madison, James Polk, Jimmy Carter, James Monroe.