Luke \l(u)-ke\ as a boy's name is pronounced look. It is of Greek origin, and the meaning of Luke is "from Lucanus". Place name: a region in southern Italy. Also sometimes used as an English form of Lucius and Lucian. Biblical: a first-century Christian, called "the beloved physician" and is patron saint of doctors and artists, who wrote one of the four Gospel accounts of the life of Christ. Lukas is a Dutch form. "Star Wars" character Luke Skywalker; actors Luke Perry, Luke Wilson.