O'Brien \o(')-brien, o'b-rien\ as a boy's name is a variant of Brian (Celtic, Irish, Gaelic), and the meaning of O'Brien is "high, noble".

The baby name O'Brien sounds like Abrian, Oberron and Oberon. Other similar baby names are Brien, Bren, Brion, Orrin, Orren, Orin, Oren and Orion.