Ulysses \u-lysses, ul(ys)-ses\ as a boy's name is pronounced you-LISS-ees. It is of Latin origin. Variant of the Greek name Odysseus, which may mean "wrathful". Mythology: Ulysses was the clever and resourceful hero of Homer's "Odyssey". Ulises is a Spanish form. American Civil War hero Ulysses S. Grant.