Andromeda \a-ndrome-da, an-dro-meda\ as a girl's name is pronounced an-DRAH-ma-dah. It is of Greek origin, and the meaning of Andromeda is "leader of men". Greek mythology: an Ethiopian princess, the daughter of Cassiopeia, was chained to a rock as a sacrifice to a sea monster until Perseus rescued her. Also a northern constellation. Also the name of a shrub that blooms in spring.