Deirdre \de(i)-rd-re, deir-dre\ as a girl's name is pronounced DEER-drah. It is of Irish and Gaelic origin, and the meaning of Deirdre is "broken-hearted, sorrowful". Also possibly "fear" or "raging woman". Mythology: from a Celtic legend similar to "Tristram and Isolde". The Celtic Deirdre was the most beautiful woman in Ireland. She died of a broken heart. Soap opera actress Deirdre Hall.