Dwayne \d-wayne, dwa(y)-ne\ as a girl's name (also used as boy's name Dwayne), is a variant of Duana (Irish, Gaelic), and the meaning of Dwayne is "dark, swarthy".

The baby name Dwayne sounds like Dayne and Dwayna. Other similar baby names are Delyne, Dagne, Dayna, Dane, Dafne, Dwan, Dawne, Deanne, Deane, Delayne, Dyanne, Dyane, Dianne, Diane, Danne, Doryne, Dwana, Duayna and Duane.