Gwen \g-wen\ as a girl's name is pronounced gwyn. It is of Welsh origin, and the meaning of Gwen is "fair, white, blessed, holy". Short form of Gwendolyn and Guinevere. In Welsh Gwen is the feminine form of Gwyn. Name of a fifth-century saint who was aunt of St David and mother of the saints Cybi and Cadfan. Often used as an independent name. Pop singer Gwen Stefani.