Karlene \k(a)-rle-ne, kar-lene\ as a girl's name is a variant of Carlene (Old German), Carly (Latin), Caroline (Old German), Charlotte (Old German), Karleen (English) and Karolina (Slavic), and the meaning of Karlene is "free man".

The baby name Karlene sounds like Karlena, Karlen, Karline and Karlyne. Other similar baby names are Karlee, Karene, Darlene, Earlene, Harlene, Kalene, Kaylene, Kailene, Kaelene and Marlene.