Madonna \m(a)-donna, mad(on)-na\ as a girl's name is pronounced ma-DAH-nah. It is of Italian origin, and the meaning of Madonna is "my lady". A form of respectful address, like the French "madame". Also used by Catholics to signify the Virgin Mary, or a work of art depicting her as a mother. Made familiar in modern times by singer/actress Madonna. See also Mona and Donna.
Madonna has 1 variant form: Madona.