Regina \r(e)-gi-na\ as a girl's name is pronounced re-JEEN-ah. It is of Latin origin, and the meaning of Regina is "queen". Appeared at the end of the Victorian era, possibly because Her Majesty was often known as Victoria Regina. May also be used as reference to the Virgin Mary, Regina Coelis, "Queen of the Heavens". Nightclub founder R?ne; track celebrity Regina Jacobs.