Sapphire \s(a)-pphi-re\ as a girl's name is pronounced SAFF-ire. It is of English origin. Jewel name and the birthstone for September. The Hebrew names Sapir and Saphira, like the English word and name Sapphire, are derived from the Hebrew term for the gem. Sapir is very rarely used, probably because the biblical Sapphira was a woman who was executed by God for lying. Safira (sa-FEER-ah) (Spanish) is based on Ceferino, from Zephyr, the name of a third-century pope.