Semele \s(e)-me-le\ as a girl's name is of Greek origin. Greek mythology: a Theban princess and the only mortal to be the parent of a god, Dionysus, by Zeus. Her name may derive from the name of an early Greek earth goddess. She was the heroine in English composer G.F. Handel's oratorio.

Semele has 2 variant forms: Samelle and Semelle.

Baby names that sound like Semele are Samale, Samala, Samuela, Samuelle, Samella and Simla.