Skyler \s-ky-ler\ as a girl's name (also used as boy's name Skyler), is pronounced SKY-ler. It is of Dutch origin, and the meaning of Skyler is "fugitive". Also possibly a phonetic form of the Dutch surname Schulyer, which was brought to New York by 17th-century settlers. Similar to Kyle or Kyla.
For more information, see also the related name Skye.