Soffrona \s(o)-ffro-na, sof(f)-rona\ as a girl's name is a variant of Sophronia (Greek), and the meaning of Soffrona is "wise".

The baby name Soffrona sounds like Saffron, Saffronia, Sophrona, Sofronja and Sofronia. Other similar baby names are Saffren, Saffran, Sefarina and Sefirina.