Winona \wi-no-na\ as a girl's name is pronounced wyw-NOH-nah. It is of Native American Indian origin, and the meaning of Winona is "first-born daughter". From Sioux Indian. Made popular by poets such as Henry Wadsworth Longfellow. Made familiar in modern times by actress Winona Ryder and country singer Wynonna Judd.
Winona has 10 variant forms: Wenona, Wenonah, Winnie, Winnona, Winoena, Winonah, Winonna, Wynnona, Wynona and Wynonna.