Zoe \zoe\ as a girl's name is pronounced ZOH-ee, ZOH. It is of Greek origin, and the meaning of Zoe is "life". Zooey is a variant from J.D. Salinger's novel "Franny and Zooey", although the character Zooey is a young man named Zachery. Popular in Greece. Actresses Zoe Caldwell, Zooey Deschanel.