Seneca \s(e)-ne-ca\ as a boy's name (also used as girl's name Seneca), is of Native American Indian origin. Name of a tribe that is part of the Iroquis confederacy. Also the name of several New York State place names, and the name of a Roman philosopher and statesman who lived around the time of Christ and was Nero's tutor.

Baby names that sound like Seneca are Sancho and Sanche. Other similar baby names are Senior, Sennett and Sennet.