Lyssa \l(ys)-sa\ as a girl's name is a variant of Alice (Old German), Alyssa (Greek), Elissa (Greek), Elizabeth (Hebrew), Larissa (Latin) and Lissa (English), and the meaning of Lyssa is "noble, exalted; rational; from the blessed isles; God's promise; God is my oath; cheerful, lighthearted".

The baby name Lyssa sounds like Lyssi and Lysa. Other similar baby names are Nyssa, Nessa, Lesya, Ilyssa, Lesia, Lesha, Lyda, Lyna, Assa, Dessa, Lissy, Elyssa, Lyza, Lyssie, Lyse, Lusa, Lissi, Lisa, Leisa, Leesa, Leasa, Elssa, Jessa, Laryssa, Lisha, Lyla, Lisia, Liesa, Lygia, Lynea, Lyvia, Luisa, Lycia, Lydia, Lynessa, Lynna, Lyria, Lyra, Nissa, Nysa, Rysa, Tassa, Tessa, Tossa and Ulyssa.