Lyssie \l(ys)-sie\ as a girl's name is a variant of Elizabeth (Hebrew), and the meaning of Lyssie is "God's promise; God is my oath".

The baby name Lyssie sounds like Lissie, Lyssi and Lassie. Other similar baby names are Cassie, Nessie, Lyssa, Gussie, Bessie, Kassie, Sissie, Cissie, Lyse, Lissi, Essie, Issie, Jessie, Kissie, Kessie, Leslie, Linsie, Lydie, Lynzie, Missie, Tassie and Tessie.